Semax was developed in Russia in the 1980s. It was initially used to prevent and treat circulatory disorders, such as strokes, heart attacks, and high blood pressure. The drug proved to be so effective that its researchers won the Prize of the Government of the Russian Federation in 2001.

Over the years, multiple small-scale human trials have been conducted to examine its ‘nootropic’ or ‘cognitive enhancing potential. This is because of the effects peptide Semax has on carboxypeptidase, an enzyme that performs various crucial functions in the human brain and body.

All these studies have proved one thing: Semax holds enormous potential as a cognitive enhancer drug. This peptide has been shown to improve memory, reduce stress and elevate mood. It has also been linked to enhanced clarity and reduction in brain fog.

The benefits of Semax aren’t limited to the brain. Animal models suggest that higher doses of Semax can increase physical performance, too, especially during high-intensity exercises. This means Semax can boost both mental and physical health.

Semax, unlike PT 141, is a neuropeptide. It was initially developed to treat circulatory disorders such as heart attack, high blood pressure, and strokes. Over the years, though, its association with the adrenocorticotropic hormone(from which it is extracted) has elevated its reputation as a cognitive enhancer. ACTH controls the production of cortisol, aka the stress hormone, in the body. This allows it to influence our mental capacities and determine how we respond in stressful situations. It also enables ACTH, and, by extension, Semax to regulate our memory, concentration, and mood.

Yet another thing that is special about conventional Semax is that it boosts our motivation. It also primes our brain to help us get a grip on behaviors like procrastination and avoidance. Plus, in situations when we need to be more alert, Semax induces a controlled state of mental stress.

On top of everything else, this experimental drug helps reduce pain in your body. This, in turn, enables it to reduce inflammation and increase the cell of immune cell activity.


  • Prevents Oxidative Stress
  • Improves Cognitive Functions
  • Increased Motivation
  • Improved Mental Clarity
  • Enhances Mood And Memory
  • Improves Blood Circulation
  • Might Treat Depression


  • Hair Loss

Since it’s a mild neuropeptide, side effects tend to be very rare with Semax use.

Semax works by chemically stimulating parts of the brain, including the hippocampus, the limbic reticular complex, and several receptors. Its effect on the receptors allows Semax to stimulate the release of the brain-derived neurotrophic factor (BDNF). That’s where things get interesting. BDNF is responsible for ensuring the survival of neurons. It enhances the shelf life of your nerve cells by helping them in their growth, maintenance, and mutation. This protein also plays a crucial role in regulating synaptic plasticity, which is vital for memory and learning.

Various studies have shown that long-term stress decreases BDNF levels in the brain. This has led researchers to conclude that a decline in BDNF levels is linked to depression, aging, and PTSD, conditions that Semax helps keep at bay by stimulating these neurotrophic factors’ release. [R] Semax has also been shown to decrease the breakdown of enkephalins. Enkephalins are naturally-occurring peptides responsible for reducing the feelings of pain in the body. Their balanced levels are necessary for excellent brain health.